SODIUM META PERIODATE LR

Sodium metaperiodate can be prepared by the dehydration of sodium hydrogen periodate with nitric acid. Na3H2IO6 + 2 HNO3 → NaIO4 

Sodium periodate can be used in solution to open saccharide rings between vicinal diols leaving two aldehyde groups. This process is often used in labeling saccharides with fluorescent molecules or other tags such as biotin.

Dosage

Dissolve sodium periodate (NaIO4) (Sigma) in 500 ml of deionized water at a concentration of 0.03-M (6.42 g). Protect from light. 2. Dissolve dextran (Polysciences) of molecular weight between 10,000 and 40,000 in the sodium periodate solution with stirring.

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