BARBITURIC ACID FOR SYNTHESIS
BARBITURIC ACID FOR SYNTHESIS: BARBITURIC ACID or malonylurea or 6-hydroxyuracil is an organic compound based on a pyrimidine heterocyclic skeleton. It is an odorless powder soluble in water. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid itself is not pharmacologically active.
| Physical state at 20 °C : | Solid |
| Odour : | Odorless |
| Odour threshold : | No data available. |
| pH value : | Not applicable |
| Melting point [°C] : | 248 - 255 °C |
| Decomposition point [°C] : | N/A |
| Critical temperature [°C] : | N/A |
| Auto-ignition temperature [°C] : | N/A |
| Flammability (solid, gas) : | N/A |
| Flash point [°C] : | 150°C |
| Boiling point [°C] : | 2600C |
| Initial boiling point [°C] : | N/A |
| Final boiling point [°C] : | N/A |
| Evaporation rate : | N/A |
| Vapour pressure [20°C] : | N/A |
| Vapour pressure mm/Hg : | N/A |
| Vapour density : | N/A |
| Density [g/cm3] : | N/A |
| Relative density, gas (air=1) : | N/A |
| Relative density, liquid (water=1) : | N/A |
| Solubility in water [% weight] : | Patially soluble in |
| Solubility in water : | N/A |
| Log Pow octanol / | No data available. |
| water at 20°C : | N/A |
| Solubility : | N/A |
| Viscosity at 40°C [mm2/s] : | N/A |
| Explosive properties : | N/A |
| Explosion limits - upper [%] : | N/A |
| Explosion limits - lower [%] : | N/A |
| Oxidising properties : | No data available |
Barbituric acid has been utilized in the design and synthesis of diverse types of heterocyclic and carbocyclic compounds and considered as an important building block in organic synthesis. There is a wide range of multicomponent reactions that include barbituric acid as starting material.
Dosage
Barbituric acid has been prepared by the action of phosphorus oxychloride on malonic acid and urea;1 by treating an acetic acid solution of urea and malonic acid with acetic anhydride;2 from diethyl malonate and urea using sodium ethoxide as a condensing agent;3 and from diethyl malonate and the sodium derivative