D-serine, (R)-2-amino-3-hydroxypropanoic acid(2R)-2-amino-3-hydroxypropanoic acid
D-Serine is a non-essential amino acid and dextro isomer of serine with antipsychotic activity. D-serine is a selective full agonist at the glycine site of N-methyl-D-aspartate (NMDA)-type glutamate receptor. Hypofunction of NMDA type of neurotransmission is believed to play a major role in pathophysiology of schizophrenia, therefore, administration of D-serine and subsequent activation of NMDA receptors may alleviate psychotic tendencies.
| CAS Number | 312-84-5 |
| Synonyms | NSC 77689 (R)-Serine |
| Molecular Formula | C3H7NO3 |
| Formula Weight | 105.1 |
| Purity | ≥95% |
| Formulation | A solid |
| Solubility PBS | 5 mg/mL |
| pH |
7.2 |
| Colour | White to off-white |
| Appearance (Form) | Crystalline compound |
| Solubility (Turbidity) 10% solution 2N HCl | Clear |
| Assay | min. 99% |
| Specific rotation [a] -13° to -14° (C=5 , | 5N HCl) |
| Loss on drying | max. 0.3% |
| Sulphated Ash | max. 0.1% |
| Iron (Fe) | max. 0.001% |
| Heavy Metals (Pb) | max. 0.001% |
| Homogeneity by TLC | Passes test |
D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.
